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| Ostegem Calcium Supplement |
The source for Vitamin K2 is MK-7's is chemical structure enables Vitamin K2 to be bound to other fat particles in circulation such as LDL (low-density lipoproteins) and set free in the bloodstream.
MK-7 thus survives longer in the circulation, manifested in its very long serum half-life and is absorbed almost completely.
Uses
Osteopenia & Osteoporosis:
As a supplement or as an adjunct to specific osteoporosis and osteopenia treatment of patients who are at risk of vitamin D and calcium deficiency.Increased nutritional requirement during pregnancy and lactation.
For bone remodeling during healing of fractures.
Dosage
Take 1 tablet once daily.Properties
Calcium
Generally, the amount of calcium absorbed through the gastrointestinal tract is approximately 30% of the swallowed dose. 99% of the calcium in the body is concentrated in the hard structure of bones and teeth. The remaining 1% is present in the intra- and extracellular fluids. About 50% of the total blood calcium content is in the physiologically active ionized form with approximately 10% being complexed to citrate, phosphate or other anions, the remaining 40% being bound to proteins, principally albumin. Calcium is eliminated through feces, urine, and sweat. Renal excretion depends on glomerular filtration and calcium tubular re-absorption.Vitamin D
Vitamin d is easily absorbed in the small intestine. Cholecalciferol and its metabolites circulate in the blood bound to a specific globulin. Cholecalciferol is converted in the liver by hydroxylation to 25-hydroxycholecalciferol. It is then further converted in the kidneys to the active form 1,25 hydroxycholecalciferol, which is the metabolite responsible for increasing calcium absorption. Vitamin d which is not metabolized is stored in adipose and muscle tissues. Vitamin D is excreted in feces and urine.Vitamin K
Following intestinal absorption, MK-7 peeks at 4 hours after intake. MK-7 does not appear to be completely removed from the circulation even after 72-96 hours and thus has a reported half-life of several days. Limited data are available regarding complete pharmacokinetic profile.Precautions & Warnings
the auction is advised in the following conditions:⦁ Long-term calcium use
⦁ Use in immobilized patients with osteoporosis
⦁ Sarcoidosis
⦁ Impaired renal function especially with the risk of hyperphosphatemia, nephrolithiasis, and nephrocalcinosis
Limited data are available regarding precautions and warnings during the use of MK-7.
Drug Interactions
Caution is advised as this preparation can interact with the following medicines:⦁ Strontium ranelate
⦁ Iron
⦁ Zinc
⦁ Thiazide diuretics
⦁ Quinolones (like ciprofloxacin, norfloxacin etc)
⦁ Tetracyclin
⦁ Bisphosphonate
⦁ Cardiac glycosides
⦁ Levothyroxine
⦁ Orlistat
Limited data are available regarding the complete interactions profile of MK-7.
Pregnancy & Lactation
Pregnancy
During pregnancy the daily intake should not exceed 1500 mg calcium and 600 IU vitamin D; studies in animals have shown reproductive toxicity of high doses of vitamin D3, In pregnant women, overdoses of calcium and vitamin D3 should be avoided as permanent hypercalcemia has been related to adverse effects on the developing fetus.Lactation
Ostegem tablets can be used during lactation. Total dose administed to the mother should be considered with regard to additional dietary inake.Contraindiations
⦁ Diseases and conditions resulting in hypercalcemia and hypercalciuria⦁ Severe renal impairment
⦁ Nephrolithiasis
⦁ Hypervitaminosis D
⦁ Hypersenstivity to soya or peanut
Side Effects or Adverse Reactions
Adverse reactions by using OSTEGEM Tablets are shown below, by system organ class and frequency.Frequencies are defined as:
uncommon (>1/1,000 to <1/100), rare (>1/10,000 to <1/1,000), or very rare (<1/10,000)Immune System Disorders
Not known: Hypersensitvity reactions such as angioedema or laryngeal edema.Metabolism and nutrition disorders
Uncommon: Hypercalcemia and hypercalciuria.
Very rare: Milk-alkali syndrome.
Gastrointestinal Disorders
Rare: Constipation, flatulence, nausea, abdominal pain, and diarrhoea.Very rare: Dyspepsia
