Sunday, October 28, 2018

Ostegem Tablets | Calcium + Vitamin D3 +Vitamin K2 Supplement

ostegem tablets
Ostegem Calcium Supplement
Ostegem Tablets complete information about uses, side effects, interactions, composition etc. Calcium in combination with vitamin d increases the intestinal absorption of calcium. Administration of calcium and vitamin D3 counteracts the increase of parathyroid hormone (PTH) which is caused by calcium deficiency and which causes increased bone resorption.



The source for Vitamin K2 is MK-7's is chemical structure enables Vitamin K2 to be bound to other fat particles in circulation such as LDL (low-density lipoproteins) and set free in the bloodstream.

MK-7 thus survives longer in the circulation, manifested in its very long serum half-life and is absorbed almost completely.

Uses

Osteopenia & Osteoporosis:

As a supplement or as an adjunct to specific osteoporosis and osteopenia treatment of patients who are at risk of vitamin D and calcium deficiency.

Increased nutritional requirement during pregnancy and lactation.

For bone remodeling during healing of fractures.

Dosage

Take 1 tablet once daily.

Properties

Calcium

Generally, the amount of calcium absorbed through the gastrointestinal tract is approximately 30% of the swallowed dose. 99% of the calcium in the body is concentrated in the hard structure of bones and teeth. The remaining 1% is present in the intra- and extracellular fluids. About 50% of the total blood calcium content is in the physiologically active ionized form with approximately 10% being complexed to citrate, phosphate or other anions, the remaining 40% being bound to proteins, principally albumin. Calcium is eliminated through feces, urine, and sweat. Renal excretion depends on glomerular filtration and calcium tubular re-absorption.

Vitamin D

Vitamin d is easily absorbed in the small intestine. Cholecalciferol and its metabolites circulate in the blood bound to a specific globulin. Cholecalciferol is converted in the liver by hydroxylation to 25-hydroxycholecalciferol. It is then further converted in the kidneys to the active form 1,25 hydroxycholecalciferol, which is the metabolite responsible for increasing calcium absorption. Vitamin d which is not metabolized is stored in adipose and muscle tissues. Vitamin D is excreted in feces and urine.

Vitamin K

Following intestinal absorption, MK-7 peeks at 4 hours after intake. MK-7 does not appear to be completely removed from the circulation even after 72-96 hours and thus has a reported half-life of several days. Limited data are available regarding complete pharmacokinetic profile.

Precautions & Warnings

the auction is advised in the following conditions:

⦁ Long-term calcium use

⦁ Use in immobilized patients with osteoporosis

⦁ Sarcoidosis

⦁ Impaired renal function especially with the risk of hyperphosphatemia, nephrolithiasis, and nephrocalcinosis

Limited data are available regarding precautions and warnings during the use of MK-7.

Drug Interactions

Caution is advised as this preparation can interact with the following medicines:

⦁ Strontium ranelate

⦁ Iron

⦁ Zinc

⦁ Thiazide diuretics

⦁ Quinolones (like ciprofloxacin, norfloxacin etc)

⦁ Tetracyclin

⦁ Bisphosphonate

⦁ Cardiac glycosides

⦁ Levothyroxine

⦁ Orlistat

Limited data are available regarding the complete interactions profile of MK-7.

Pregnancy & Lactation

Pregnancy

During pregnancy the daily intake should not exceed 1500 mg calcium and 600 IU vitamin D; studies in animals have shown reproductive toxicity of high doses of vitamin D3, In pregnant women, overdoses of calcium and vitamin D3 should be avoided as permanent hypercalcemia has been related to adverse effects on the developing fetus.

Lactation

Ostegem tablets can be used during lactation. Total dose administed to the mother should be considered with regard to additional dietary inake.

Contraindiations

⦁ Diseases and conditions resulting in hypercalcemia and hypercalciuria

⦁ Severe renal impairment

⦁ Nephrolithiasis

⦁ Hypervitaminosis D

⦁ Hypersenstivity to soya or peanut

Side Effects or Adverse Reactions

Adverse reactions by using OSTEGEM Tablets are shown below, by system organ class and frequency.

Frequencies are defined as:

uncommon (>1/1,000 to <1/100), rare (>1/10,000 to <1/1,000), or very rare (<1/10,000)

Immune System Disorders

Not known: Hypersensitvity reactions such as angioedema or laryngeal edema.

Metabolism and nutrition disorders

Uncommon: Hypercalcemia and hypercalciuria.

Very rare: Milk-alkali syndrome.

Gastrointestinal Disorders

Rare: Constipation, flatulence, nausea, abdominal pain, and diarrhoea.

Very rare: Dyspepsia

Skin and subcutaneous tissue disorders

Very rare: Pruritus, rash and urticaria.

Overdose

Overdose can lead to hypervitaminosis and hypercalcemia. Milk alkali syndrome may also occur. Limited data are available regarding overdose related to MK-7.

Treatment of Overdose:

The OSTEGEM tablets must be discontinued. Treatment with thiazide diuretics, lithium, vitamin A, vitamin D, and cardia glycosides must also be discontinued. Emptying the stomach in patients with impaired consciousness must be done. Serum electrolytes, renal function and diuresis must be monitored.

Storage:

Store below 25 degree centigrades.

Zeeshan

About Zeeshan

Zeeshan is professional blogger who provide information about Prescription drugs and their Indications, Side effects, Interactions, Dosage information online on medi-cin.blogspot.com.

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